Genome Sequencing Uncovers New Autoimmune Syndrome
Using technology that allows scientists to read the script of a person’s DNA, scientists have found a new autoimmune disease syndrome that combines severe lung disease and arthritis.
Key Genetic Factor Behind Autoimmune Diseases and Cancer Is Identified
Scientists at Yale have uncovered a molecular mechanism that causes variants in a specific immune response gene known as MIF (macrophage migration inhibitory factor).
Potential Tobacco-Based Vaccine Could Rival Egg-Based Vaccines
A new tobacco-based seasonal influenza vaccine being developed by Mitsubishi Tanabe Pharma and currently in Phase III studies could potentially rival traditional chicken egg-based vaccines.
Scientists Find a Potential Cure for Cancer
Scientists from Harvard, MIT and University College London have made a discovery about the genetics of cancer tumors that could offer a new way to deliver customized immunotherapy drugs to kill all types of cancer, including the most complex such as melanoma and lung cancer.
Meta-Analysis Reveals No Evidence that IVIG Administration Increases Risk of Thromboembolic Events
Analysis of 31 randomized controlled trials (RCTs) published between 1995 and 2015 found no evidence of increased thromboembolic event (TEE) risk among patients treated with intravenous immune globulin (IVIG) compared to control patients, according to a report by a team of investigators that included epidemiologists at the U.S. Food and Drug
Administration.
Single IVIG Infusion Associated with Improved Recovery and Histopathological Profile in Rat Model of Ischemic Stroke
Turkish investigators conducted an exploratory study of IVIG usage in the experimentally induced middle cerebral artery occlusion rat stroke model.
ProMetic Completes First Dosing in Plasminogen Deficiency Patients
In its Phase I clinical trial, ProMetic Life Sciences successfully completed its first round of IV plasminogen dosing in plasminogen deficiency patients.
Inhaled Alpha-1 Proteinase Inhibitor Safe, Well-Tolerated and Effective in Raising Sputum Levels in Patients with Cystic Fibrosis
Inhalation of aerosolized alpha-1 proteinase inhibitor (A1PI) permits delivery of drug to the site of active airway disease while limiting systemic exposure, and has been shown to reduce neutrophil elastase burden and inflammation in respiratory secretions of alpha-1 antitrypsin-deficient patients.
Biomarker Found in CIDP Patients Who Don’t Respond to IVIG Therapy
A recent study discovered a biomarker in chronic inflammatory demyelinating polyneuropathy patients that explains why they don’t respond to intravenous immune globulin therapy.
Engineered Protein Controls Bleeding in Severe VWD
Results of a Phase III study show that BAX 111, a highly purified recombinant von Willebrand factor analog manufactured by Baxalta, appeared safe and effective for treatment of bleeding episodes in patients with severe von Willebrand’s disease.
