Clinical Trials Archives

NIH Provides $5.3 Million Grant to Study Down Syndrome

The first clinical trial for Down syndrome regression disorder is being funded by a five-year $5.3 million grant.

First Human Clinical Trial of Cancer Killing Virus Has Begun

A clinical trial of the Vaxina (the CF33-hNIS virus) designed to kill cancer cells has begun.

Plasma Prekallikrein Inhibition by Antisense Oligonucleotide Reduces Hereditary Angioedema Disease Burden

An investigational antisense oligo-nucleotide (donidalorsen) that acts by degrading plasma prekallikrein messenger RNA was evaluated in patients with hereditary angioedema (HAE) and C1 inhibitor deficiency to assess whether this agent can reduce the frequency of angioedema attacks and the burden of disease.

Many Clinically Stable CIDP Patients Can Safely Stop IVIG Maintenance Treatment

While intravenous immune globulin (IVIG) therapy is efficacious for patients with chronic inflammatory demyelinating polyneuropathy (CIDP), the lack of biomarkers for disease activity makes the need for ongoing treatment difficult to assess.

Addition of Eltrombopag Improves Efficacy of Standard Therapy for Aplastic Anemia

Eltrombopay found to improve therapy for aplastic anemia.

Neonatal Fc Receptor Blockers for Myasthenia Gravis: The Concept Is Now Reality

While acetylcholinesterase inhibitors, corticosteroids and thymectomy are generally considered first-line therapies for MG, many patients additionally require proven immunosuppressive therapies (ISTs) such as azathioprine, cyclosporine/tacrolimus or mycophenolate mofetil, or immunomodulatory therapies, including intravenous immune globulin (IVIG) or plasma exchange (PLEX).