WHO Publishes First Guidelines for Treating Ebola

The World Health Organization has published its first guideline for Ebola virus disease therapeutics, with new strong recommendations for the use of two monoclonal antibodies.

RNA Interference Therapeutic Reduces Hepatotoxic Mutant Z-AAT Levels in Patients with Alpha1-Antitrypsin Deficiency

In a Phase II trial of participants with hepatic disease associated with congenital alpha1-antitrypsin deficiency, subcutaneous administration of fazirsitran, an investigational RNA interference therapeutic, reduced both serum and hepatic levels of the mutant hepatotoxic AAT protein Z-AAT, with concurrent improvements in enzymatic and histological markers of liver function.

Antibody Targeting Tissue Factor Pathway Inhibitor (TFPI) Sharply Reduces Bleeding Rate in Hemophilia A and B Patients

Subcutaneous administration of marstacimab, an investigational human monoclonal antibody targeting tissue factor pathway inhibitor, resulted in a roughly 10-fold lower annualized bleeding rate in 26 hemophilia patients than comparable control individuals in previous clinical trials who were treated on-demand with recombinant factor replacement therapy.

Myths & Facts: COVID-19

While the COVID-19 pandemic is “officially over,” hospitalizations and deaths continue, many of which are due to the myths continuing to circulate about this deadly virus.

The Burden of Lyme Disease

Research into effective treatments for this complicated disease is elusive — and necessary.

Addressing the Mental Health Crisis in Children

The pandemic made a troubling mental health trend in children much worse. What’s being done to help them?

Update on Treatment Options for Alzheimer’s

While a cure for Alzheimer’s remains elusive, new diagnostic tools and treatment options are improving patient quality of life. 

Fitusiran Prophylaxis Reduces Bleeds Versus Prior Factor or Bypassing Agent Prophylaxis in Hemophilia A and B Patients

Sanofi’s fitusiran significantly reduced bleeding in a Phase III multinational study in adults and adolescents with hemophilia A or B, with or without inhibitors.

IVIG May Reverse Symptoms of Down Syndrome Regression Disorder

A new study shows treatment with IVIG shows promise for children and young adults with Down syndrome regression disorder (DSRD). 

Flu Vaccines Poor Match to Influenza Strains This Season

According to CDC, this season’s influenza (flu) vaccines offered meager protection against mild cases of influenza.