Meta-Analysis Reveals No Evidence that IVIG Administration Increases Risk of Thromboembolic Events
Analysis of 31 randomized controlled trials (RCTs) published between 1995 and 2015 found no evidence of increased thromboembolic event (TEE) risk among patients treated with intravenous immune globulin (IVIG) compared to control patients, according to a report by a team of investigators that included epidemiologists at the U.S. Food and Drug
Administration.
Single IVIG Infusion Associated with Improved Recovery and Histopathological Profile in Rat Model of Ischemic Stroke
Turkish investigators conducted an exploratory study of IVIG usage in the experimentally induced middle cerebral artery occlusion rat stroke model.
ProMetic Completes First Dosing in Plasminogen Deficiency Patients
In its Phase I clinical trial, ProMetic Life Sciences successfully completed its first round of IV plasminogen dosing in plasminogen deficiency patients.
Inhaled Alpha-1 Proteinase Inhibitor Safe, Well-Tolerated and Effective in Raising Sputum Levels in Patients with Cystic Fibrosis
Inhalation of aerosolized alpha-1 proteinase inhibitor (A1PI) permits delivery of drug to the site of active airway disease while limiting systemic exposure, and has been shown to reduce neutrophil elastase burden and inflammation in respiratory secretions of alpha-1 antitrypsin-deficient patients.
Biomarker Found in CIDP Patients Who Don’t Respond to IVIG Therapy
A recent study discovered a biomarker in chronic inflammatory demyelinating polyneuropathy patients that explains why they don’t respond to intravenous immune globulin therapy.
Engineered Protein Controls Bleeding in Severe VWD
Results of a Phase III study show that BAX 111, a highly purified recombinant von Willebrand factor analog manufactured by Baxalta, appeared safe and effective for treatment of bleeding episodes in patients with severe von Willebrand’s disease.
New Type of Sound Wave May Allow for Inhalable Vaccines
A new form of hybridized sound waves developed by Australian researchers may allow drugs and vaccines to be delivered to the body through a nebulizer in a fine mist inhaled into the lungs.
Cancer-Causing Gene Found in Plasma May Help Predict Outcomes for Patients
University of Cincinnati researchers have discovered that a human cancer-causing gene, called DEK, can be detected in the plasma of head and neck cancer patients.
Short Course of IVIG May Slow Brain Atrophy and Conversion to Dementia in Persons with MCI Stage Alzheimer’s Disease
An exploratory controlled, randomized, double-blind study was conducted by investigators at the Sutter Neuroscience Institute in Sacramento to determine whether a single course of
intravenous immune globulin (IVIG) influences the rate of brain atrophy and cognitive function in mild cognitive impairment (MCI) due to Alzheimer’s disease (AD).
Stroke Drug May Halt Progression of Alzheimer’s
Scientists at the University of South Australia and colleagues from Third Military Medical University in Chongqing, China, have found that the drug Edaravone alleviates Alzheimer’s disease pathologies at multiple levels and improves learning and memory functions in mice.
