Fitusiran Prophylaxis Reduces Bleeds Versus Prior Factor or Bypassing Agent Prophylaxis in Hemophilia A and B Patients
Sanofi’s fitusiran significantly reduced bleeding in a Phase III multinational study in adults and adolescents with hemophilia A or B, with or without inhibitors.
Novel Immunotherapies Target RSV Disease at Both Ends of the Age Spectrum
RSV infections account for a large share of U.S. hospitalizations for lower respiratory tract disease due in large part to a lack of immunization and prophylactic therapies, but new developments and cutting-edge therapies may soon become standard medical practice.
High-Dose IVIG Effective in Painful Diabetic Polyneuropathy Resistant to Conventional Treatments
Italian investigators conducted a trial to assess the safety and efficacy of IVIG in treatment-resistant painful diabetic polyneuropathy (DPN).
Neonatal Fc Receptor Blockers for Myasthenia Gravis: The Concept Is Now Reality
While acetylcholinesterase inhibitors, corticosteroids and thymectomy are generally considered first-line therapies for MG, many patients additionally require proven immunosuppressive therapies (ISTs) such as azathioprine, cyclosporine/tacrolimus or mycophenolate mofetil, or immunomodulatory therapies, including intravenous immune globulin (IVIG) or plasma exchange (PLEX).
The Current Challenge of Immune Globulin Access
Understanding the factors contributing to the current shortage of immune globulin could help to address a crisis that threatens dire consequences for patients.
High Oncotic Pressure Cardiopulmonary Bypass Priming with Human Albumin Improves Outcomes in Pediatric Open-Heart Surgery
Specialists at India’s Sir Ganga Ram Hospital conducted a double-blinded, randomized controlled study to examine the impact of high oncotic pressure priming by the addition of 20 percent human albumin prior to the initiation of CPB
First-Line Intravenous Immune Globulin Monotherapy Evaluated in Idiopathic Inflammatory Myopathy
The investigators concluded first-line IVIG monotherapy led to clinically relevant improvement in nearly one-half of IIM patients, the majority of whom experienced a rapid clinical response.
Predictive Medicine: How DNA Testing Is Influencing Healthcare
Will genetic testing and whole genome sequencing become part of the standard of care in treating patients?
Live Donor Organ Transplant: A Physician’s Perspective
Nancy Ascher, MD, PhD, has devoted her career to organ transplantation and transplant surgery.
Anti-COVID Monoclonal Cocktails
Newly created treatments for high-risk COVID-19 patients have proved highly effective. Unfortunately, challenges with their distribution and administration have limited their use.
